Frameworks can be a powerful tool when doing CSS layouts. They handle the type setting, give you tools to rapidly build cross platform layouts and generally remove a lot of the headaches that happen. Blueprint is one of the most powerful tools available to do grid based layouts as endorsed by Khoi Vinh.

How it works. Blueprint provides a basic 14 column layout grid with all styles reset. It also gives powerful support for an 18px baseline and several useful CSS tweaks.

The true power of Blueprint is the grid. It allows you to simply define blocks based on how many grid units they should occupy & then blueprint handles the rest. Blocks can be nested within each other which allows for the creation of extremely complex layouts without needing to resort to complex CSS hacks or overly baroque markup.

You can download Blueprint at http://code.google.com/p/blueprintcss/